Critical Limb Ischemia Criteria help doctors determine whether reduced blood flow has become severe enough to threaten the limb. Common warning signs include persistent pain, especially at rest, wounds that do not heal, ulcers, or gangrene. Doctors may also use tests such as the ankle-brachial index, toe pressure measurements, Doppler ultrasound, or vascular imaging to assess circulation. Looking at both the patient’s symptoms and test results gives a more complete picture of how seriously the blood flow is affected. Advancells, India is leading supplier of stem cells for chronic diseases like CLI.